TrkB knockout mice die early in postnatal life due to an inability to feed.
A. In the current model for neurotrophin and receptor function, pro-neurotrophins have high affinity for p75NTR, while mature neurotrophins act through one or more Trk receptors. Based on Figure Q7-22, would you expect a BDNF knockout mouse to have a more or less severe phenotype than the TrkB knockout? Briefly explain your reasoning. Figure Q7-22
B. Now consider the observation that many, perhaps most, neurons that express TrkB also express TrkA or TrkC. How does this alter your prediction?
Assembly of Olfactory Circuits: How Do Neural Maps Form?

Question

TrkB knockout mice die early in postnatal life due to an inability to feed.
A. In the current model for neurotrophin and receptor function, pro-neurotrophins have high affinity for p75NTR, while mature neurotrophins act through one or more Trk receptors. Based on Figure Q7-22, would you expect a BDNF knockout mouse to have a more or less severe phenotype than the TrkB knockout? Briefly explain your reasoning.  Figure Q7-22
B. Now consider the observation that many, perhaps most, neurons that express TrkB also express TrkA or TrkC. How does this alter your prediction?
Assembly of Olfactory Circuits: How Do Neural Maps Form?

Quizplus · Accepted Answer

The Answer of TrkB knockout mice die early in postnatal life due to an inability to feed.
A. In the current model for neurotrophin and receptor function, pro-neurotrophins have high affinity for p75NTR, while mature neurotrophins act through one or more Trk receptors. Based on Figure Q7-22, would you expect a BDNF knockout mouse to have a more or less severe phenotype than the TrkB knockout? Briefly explain your reasoning.  Figure Q7-22
B. Now consider the observation that many, perhaps most, neurons that express TrkB also express TrkA or TrkC. How does this alter your prediction?
Assembly of Olfactory Circuits: How Do Neural Maps Form?

TrkB Knockout Mice Die Early in Postnatal Life Due to an Inability