The clustering of acetylcholine receptors in the vertebrate neuromuscular junction requires all of the following except:
A) agrin.
B) LRP4.
C) a muscle-specific receptor tyrosine kinase.
D) innervating motor axons.
E) None of the above

Question

Quizplus · Accepted Answer

AChR clusters form at the appropriate location in the absence of innervating motor axons. However, in the presence of motor axons, Agrin, Lrp4, and MuSK knockouts exhibit severe defects in clustering.

The Clustering of Acetylcholine Receptors in the Vertebrate Neuromuscular Junction