How does curcumin treatment lead to a normalization of chloride transport in mice with the cystic fibrosis transmembrane conductance regulator (CFTR) DF508 mutation?

Question

Quizplus · Accepted Answer

Curcumin treatment leads to a normalization of chloride transport in mice with the CFTR DF508 mutation by preventing the retention and degradation of CFTR in the endoplasmic reticulum. This allows more of the mutant CFTR protein to reach the cell surface where it can function in chloride transport.

How Does Curcumin Treatment Lead to a Normalization of Chloride