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How Might Gentamicin Be a Therapy for Individuals with a Nonsense

Question 12

Multiple Choice

How might gentamicin be a therapy for individuals with a nonsense mutation in CFTR?


A) It causes misincorporation of an amino acid at the nonsense codon
B) It is a cofactor for the CFTR protein
C) It prevents retention and degradation of CFTR in the endoplasmic reticulum
D) It causes upregulation of the CFTR gene
E) It prevents transport of the mutant CFTR to the lysosome

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