Polyethylene Glycol Modification of Adenosine Deaminase for Enzyme Replacement Therapy

Polyethylene glycol modification of adenosine deaminase for enzyme replacement therapy has which of the following effects?

A) Enhances the catalytic activity of the enzyme
B) Reduces likelihood of eliciting a neutralizing antibody response to the protein
C) Enhances cofactor binding of the enzyme
D) Stabilizes the protein conformation
E) All of the above