What severe side effect was observed in one gene therapy trial for X-linked severe combined immune deficiency (SCID)?

Question

Quizplus · Accepted Answer

In one gene therapy trial for X-linked severe combined immune deficiency (SCID), a severe side effect observed was the development of a malignant lymphoproliferative disorder in some of the treated patients. This was linked to the insertion of the therapeutic gene near an oncogene in the patient's DNA, leading to uncontrolled cell growth.

What Severe Side Effect Was Observed in One Gene Therapy