A 17-Year-Old Girl Comes to the Office for Evaluation of a Generalized

A 17-year-old girl comes to the office for evaluation of a generalized rash.  The rash was present when she woke up this morning and does not feel painful or itchy.  For the past 10 days, the patient has had a sore throat, fever, fatigue, and body aches.  She had a bottle of amoxicillin from a recent episode of pharyngitis and took a few pills this week, but the symptoms did not resolve.  Her only medical problem was major depression, which resolved with behavioral therapy 3 years ago.  She is sexually active and takes oral contraceptive pills.  The patient takes no other medications.  She does not use tobacco, alcohol, or illicit drugs.  Temperature is 38 C (100.4 F) , blood pressure is 110/76 mm Hg, pulse is 88/min, and respirations are 16/min.  Physical examination demonstrates an awake but tired-appearing adolescent.  There is no rhinorrhea, tympanic membranes are clear, and tonsils are enlarged and erythematous with white exudate bilaterally.  There is tender cervical lymphadenopathy but no neck stiffness.  S1 and S2 are normal.  Lungs are clear to auscultation bilaterally.  The abdomen is soft and nontender with mild hepatosplenomegaly.  A diffuse, erythematous, blanching, maculopapular rash is seen on the chest, abdomen, and extremities.  Laboratory results are as follows:
An appropriate diagnosis is made and the correct management is initiated.  Which of the following is a true statement about the patient's condition?

A) Close sexual contacts of the patient should be identified, tested, and offered treatment
B) Many symptoms will resolve spontaneously, but fatigue can persist for months
C) The patient should be placed on contact isolation precautions until the rash resolves
D) The patient should not receive beta lactam antibiotics in the future
E) The rash generally will not resolve until the underlying illness is fully treated