A 63-year-old man comes to the physician because of sudden severe pain in the right knee. He has a long history of gouty arthritis, and his current symptoms are similar to previous flares of the disease. he has been diagnosed with peptic ulcer disease His temperature is 38.0°C (100.4°F). Examination shows erythema, edema, and warmth of the right knee; range of motion is limited by pain. Arthrocentesis of the knee joint yields cloudy fluid with a leukocyte count of 24,000/mm3 (74% segmented neutrophils). Polarized light microscopy shows needle-shaped, negatively birefringent crystals. The patient is started on a new medication for gout that provides significant relief of his symptoms, but he returns to the clinic a week later with diarrhea and persistent nausea. The drug used in this patient most likely affects which of the following cell structures?

Question

A 63-year-old man comes to the physician because of sudden severe pain in the right knee. He has a long history of gouty arthritis, and his current symptoms are similar to previous flares of the disease. he has been diagnosed with peptic ulcer disease His temperature is 38.0°C (100.4°F). Examination shows erythema, edema, and warmth of the right knee; range of motion is limited by pain. Arthrocentesis of the knee joint yields cloudy fluid with a leukocyte count of 24,000/mm3 (74% segmented neutrophils). Polarized light microscopy shows needle-shaped, negatively birefringent crystals. The patient is started on a new medication for gout that provides significant relief of his symptoms, but he returns to the clinic a week later with diarrhea and persistent nausea.  The drug used in this patient most likely affects which of the following cell structures?

Quizplus · Accepted Answer

Eductional Objective: Colchicine inhibits tubulin polymerization into microtubules and can be used for acute treatment and prophylaxis of gout.  Important side effects of colchicine include nausea, abdominal pain, and diarrhea.

A 63-Year-Old Man Comes to the Physician Because of Sudden