A 14-year-old boy is brought to the hospital by his mother after an episode of generalized body shaking. He looks confused and lethargic. Physical examination shows a tongue laceration , otherwise unremarkable. His seizures have been refractory to various antiepileptic medications, and he is started on lamotrigine. The patient should be instructed to see his physician immediately if which of the following symptoms occurs?

Question

A 14-year-old boy is brought to the hospital by his mother after an episode of generalized body shaking. He looks confused and lethargic.  Physical examination shows a tongue laceration , otherwise unremarkable. His seizures have been refractory to various antiepileptic medications, and he is started on lamotrigine.  The patient should be instructed to see his physician immediately if which of the following symptoms occurs?

Quizplus · Accepted Answer

Eductional Objective: Lamotrigine can be used to treat partial and generalized seizures and works by blocking voltage-gated sodium channels. Stevens-Johnson syndrome and toxic epidermal necrolysis are rare, life-threatening adverse effects characterized by flu-like symptoms followed by widespread mucocutaneous epidermal necrosis.

A 14-Year-Old Boy Is Brought to the Hospital by His