A 64-year-old man comes to the physician because of a history of progressively worsening back pain that wakes him up at night. He also reports symptoms of urinary urgency and a weak urine stream. He has no history of serious illness and takes no medications. Rectal examination shows an enlarged and hardened prostate with a nodular surface. Spinal imaging reveals multiple lesions suspicious for metastatic cancer. Biopsy of a bone lesion shows well-differentiated adenocarcinoma. Treatment with a medication that does which of the following would most likely reduce the spread of this patient's cancer?

Question

A 64-year-old man comes to the physician because of a history of progressively worsening back pain that wakes him up at night. He also reports symptoms of urinary urgency and a weak urine stream. He has no history of serious illness and takes no medications. Rectal examination shows an enlarged and hardened prostate with a nodular surface. Spinal imaging reveals multiple lesions suspicious for metastatic cancer.  Biopsy of a bone lesion shows well-differentiated adenocarcinoma.  Treatment with a medication that does which of the following would most likely reduce the spread of this patient's cancer?

Quizplus · Accepted Answer

Eductional Objective: Patients with advanced or castration-resistant prostate cancer are often treated with an 17-alpha-hydroxylase inhibitors (eg, abiraterone), which block the generation of androgens in the adrenal glands, testes, and tumor cells.  This reduces systemic androgen levels, which limit prostate cancer growth.

A 64-Year-Old Man Comes to the Physician Because of a History