Resistant Hypertension Has Been Diagnosed in a 46-Year-Old Man

Resistant hypertension has been diagnosed in a 46-year-old man. He had a thorough workup for secondary hypertension, which revealed nothing. The patient has tried several antihypertensive medications with no success. Otherwise, the patient's medical history is unremarkable. He agrees to participate in a study of a new long-acting medication that causes selective direct relaxation of arteriole smooth muscle but has no effect on veins. Which of the following adverse effects is most likely to be caused by the drug during the clinical trial?

A) Angioedema
B) Bradycardia
C) Cold extremities
D) Decreased cardiac output
E) Persistent cough
F) Sodium and fluid retention
G) Transient hypertension