Hemoglobin electrophoresis of a 2-year-old patient showed migration of A₂ and F on cellulose acetate at pH 8.4. Quantitation studies showed 5% A₂ and 95% F. What thalassemia is most likely present?

Question

Quizplus · Accepted Answer

The presence of F on electrophoresis indicates beta thalassemia, while the presence of A₂ suggests a heterozygous alpha-thalassemia trait. Therefore, the most likely diagnosis is beta thalassemia. There is no evidence to support the presence of sickle cell trait or disease, so choices C and D can be ruled out. Choice A, alpha thalassemia alone, would not typically result in F on electrophoresis.

Hemoglobin Electrophoresis of a 2-Year-Old Patient Showed Migration of A2

Hemoglobin Electrophoresis of a 2-Year-Old Patient Showed Migration of A₂