The main concern(s) regarding patients with thalassemia major treated with hypertransfusion include(s):

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Thalassemia major patients require frequent blood transfusions to survive, which can lead to iron overload, alloimmunization, and potential transmission of infectious diseases. Iron overload can cause damage to organs such as the heart, liver, and pancreas, while alloimmunization can lead to difficulty finding compatible blood for future transfusions. Transfusion-transmitted diseases such as hepatitis B, hepatitis C, and HIV are also a concern. Therefore, all of the options (A, B, and C) are valid concerns for thalassemia major patients treated with hypertransfusion.

The Main Concern(s) Regarding Patients with Thalassemia Major Treated with Hypertransfusion