What thalassemia-associated variant will result in sickling crisis in severe hypoxic conditions?

Question

Quizplus · Accepted Answer

Beta thalassemia/hemoglobin S is the genotype associated with sickle cell disease, which results in sickling of the red blood cells in deoxygenated conditions leading to vaso-occlusion and pain crises. This is the most severe form of thalassemia-associated sickling. The other options are not specifically associated with sickling crises.

What Thalassemia-Associated Variant Will Result in Sickling Crisis in Severe