A 5-year-old boy presents with a hemoglobin and hematocrit of 10 g/dL and 30% respectively, a serum bilirubin of 3.0 mg/dL, a RBC count of 4.0 million/µL, and splenomegaly. Which clinical expression of thalassemia best correlates with the data?

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The clinical presentation suggests thalassemia intermedia due to the moderate anemia, increased bilirubin indicating hemolysis, and splenomegaly without the severe anemia typical of thalassemia major or the mild or asymptomatic presentation of thalassemia minor. Bart's hydrops fetalis and HPFH (Hereditary Persistence of Fetal Hemoglobin) present differently.

A 5-Year-Old Boy Presents with a Hemoglobin and Hematocrit of 10