A 13-year-old boy presents with the following hematologic results: RBC = 5.76 million, Hb, 10.4 g/dL; Hct, 35.9%; MCV (mean corpuscular volume), 63 fL: MCH (mean corpuscular hemoglobin), 18.2 pg; MCHC (mean corpuscular hemoglobin concentration), 29%; and RDW (red blood cell distribution width), 13.5. Morphology includes mild anisocytosis and occasional target cells. All iron studies are normal. Electrophoresis on cellulose acetate at pH 8.4 indicates an increase in HbF and HbA₂. What thalassemia syndrome is evident?

Question

Quizplus · Accepted Answer

The presence of increased HbF and HbA alongside the hematologic findings (low MCV and MCH with normal iron studies) suggests β-thalassemia. The findings are consistent with β-thalassemia, where there is a defect in β-globin chain production, leading to microcytic anemia.

A 13-Year-Old Boy Presents with the Following Hematologic Results: RBC