In pancreatic adenocarcinoma,the tumor cells are surrounded by dense stromal tissue,making drug delivery to the cancer cells difficult.Recent studies in mice have shown improved delivery of the drugs gemcitabine and doxorubicin to pancreatic adenocarcinoma cells when concomitantly administered with antagonists of

Question

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Recent studies have shown that antagonists of the Hedgehog signaling pathway can improve drug delivery to pancreatic adenocarcinoma cells due to the activation of a desmoplastic reaction that reduces the stromal density, allowing better penetration of drugs. The other options (A, B, and D) are not directly related to the dense stromal tissue surrounding pancreatic adenocarcinoma cells.

In Pancreatic Adenocarcinoma,the Tumor Cells Are Surrounded by Dense Stromal