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The most commonly used method in human chromosome banding is known as ___1___-banding, when the chromosomes are treated with trypsin and then stained with the ____2____ dye. The ____2____ dye binds preferentially to ___3____-rich regions in DNA and the staining produces a series of alternating ____4____ bands that are ____2___-positive and ___3____-rich and ____5____ bands that are ____2___-negative and ___6____-rich. The ____4____ bands have a generally ____7____ content of genes, whereas the ____5____ bands have a ____8____ content of genes.