Proteins bind selectively to small-molecule targets called ligands.The selection of one ligand out of a mixture of possible ligands depends on the number of weak, noncovalent interactions in the protein's ligand-binding site.Where is the binding site typically located in the protein structure?

Question

Quizplus · Accepted Answer

The binding site is typically located inside a cavity on the protein surface. This allows for specific interactions between the ligand and amino acid residues lining the cavity, while also shielding the ligand from solvent molecules.

Proteins Bind Selectively to Small-Molecule Targets Called Ligands