For Each of the Following Sentences, Fill in the Blanks

For each of the following sentences, fill in the blanks with the best word or phrase selected from the list below.Not all words or phrases will be used; each word or phrase should be used only once.
$\begin{array}{lll}\text { activation energy } & \text { inhibitors } & \text { products } \\\text { active site } & \text { isomers } & \text { substrates } \\\text { free energy } & \text { ligand } & \text { transition state } \\\text { high-energy } & \text { low-energy } &\end{array}$

Any substance that will bind to a protein is known as its __________.Enzymes bind their __________ at the __________.The enzyme hexokinase is so specific that it reacts with only one of the two __________ of glucose.Enzymes catalyze a chemical reaction by lowering the __________, because they provide conditions favorable for the formation of a __________ intermediate called the __________.Once the reaction is completed, the enzyme releases the __________ of the reaction.