Denaturation is a process in which proteins lose their natural shape and order of assembly and, therefore, their biological functions. Which of the following statements is/are true?
I. In quaternary structure denaturation, protein sub-units are dissociated.
II. In tertiary structure denaturation, covalent and ionic bonds are predominantly formed.
III. In tertiary structure denaturation, covalent and ionic bonds are disrupted.
IV. In quaternary structure denaturation, proteins lose all regular repeating patterns, such as alpha-helices and beta-pleated sheets.

Question

Quizplus · Accepted Answer

I is correct as quaternary structure refers to the arrangement of multiple protein subunits. Denaturation can cause these subunits to dissociate from each other. 
II is incorrect as covalent and ionic bonds are disrupted in tertiary structure denaturation, not formed. 
III is correct as disruption of covalent and ionic bonds in tertiary structure denaturation leads to loss of natural shape and function. 
IV is not related to quaternary structure denaturation and is therefore incorrect.

Denaturation Is a Process in Which Proteins Lose Their Natural