Denaturation is a process in which proteins lose their natural shape and order of assembly and, therefore, their biological functions. Which of the following statements is/are true?
I. In secondary denaturation, some of the amide-bonds of the proteins´ backbones are hydrolyzed.
II. In secondary structure denaturation, proteins lose all regular repeating pattern, such as alpha-helices and beta-pleated sheets.
III. In secondary structure denaturation, proteins adopt random-coil conformations.
IV. In secondary structure denaturation, noncovalent dipole-dipole interactions between polar amino acids/side chains and the solvent are disrupted.

Question

Quizplus · Accepted Answer

II and III are correct because denaturation affects the secondary structure of proteins by disrupting the regular repeating patterns such as alpha-helices and beta-pleated sheets, leading to a random-coil conformation.

Denaturation Is a Process in Which Proteins Lose Their Natural