The Applications of the Yeast Two-Hybrid Method Include All of the Following

The applications of the yeast two-hybrid method include all of the following EXCEPT

A) mapping protein-protein interactions in E. coli.
B) identifying of physiologically significant protein-protein interactions as potential antibiotic targets.
C) finding unknown proteins ("prey") that interact with proteins of known functions ("bait") .
D) mapping protein-protein interactions in M. tuberculosis.
E) the ability to probe interactions in vivo.