Nucleosomes that are positioned like beads on a string over a region of DNA can interact to form higher orders of chromatin structure. Which of the following factors can contribute to the formation of the 30-nm chromatin fiber from these nucleosomes?

Question

Quizplus · Accepted Answer

Chromatin structure is highly dynamic, undergoing tightly regulated conformational rearrangements. In the formation of the 30-nm fiber, in addition to the interactions of histone tails (such as the H4 tail) with neighboring nucleosomes and the 1-to-1 deposition of the linker histone H1, non-histone proteins that bind to the nucleosomes also play important roles. Among these are the chromatin remodeling complexes that can slide the nucleosomes in order to attain optimal positioning on the DNA.

Nucleosomes That Are Positioned Like Beads on a String Over