Indicate whether each of the following descriptions better matches the major histones (M) or the histone variants (V). Your answer would be a six-letter string composed of letters M and V only, e.g. VVMVMV.
( ) They are more highly conserved over long evolutionary time scales.
( ) They are present in much smaller amounts in the cell.
( ) They are synthesized primarily during the S phase of the cell cycle.
( ) Their incorporation often requires histone exchange.
( ) They are often inserted into already-formed chromatin.
( ) They are assembled into nucleosomes just behind the replication fork.

Question

Indicate whether each of the following descriptions better matches the major histones (M) or the histone variants (V). Your answer would be a six-letter string composed of letters M and V only, e.g. VVMVMV.
( )	They are more highly conserved over long evolutionary time scales.
( )	They are present in much smaller amounts in the cell.
( )	They are synthesized primarily during the S phase of the cell cycle.
( )	Their incorporation often requires histone exchange.
( )	They are often inserted into already-formed chromatin.
( )	They are assembled into nucleosomes just behind the replication fork.

Quizplus · Accepted Answer

Compared to the histone variants, the major histones are more highly conserved, are much more abundant, and become available in a burst of synthesis at S phase in order to associate with the newly replicated, histone-deficient, DNA molecules.

Indicate Whether Each of the Following Descriptions Better Matches the Major