A 13-year-old boy with growth retardation, microcephaly, sun sensitivity, and recurring infections is being examined for a hereditary genetic abnormality. The patient is the second kid born from a first cousin marriage. His parents and siblings are all OK, however two of his maternal relatives are experiencing identical indications and symptoms. The patient's genetic investigation indicates a deficiency in the BLM gene, which codes for DNA helicase. Which of the following is the enzyme's most likely place of action in the DNA replication fork depicted below?

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Eductional Objective: Bloom syndrome is an autosomal recessive disorder caused by mutations in the BLM gene, which codes for helicase, an enzyme that unwinds the double helix during DNA replication. Due to chromosomal instability and breakage, patients often manifest with growth retardation, facial abnormalities, photosensitive skin rash, and immunodeficiency.

A 13-Year-Old Boy with Growth Retardation, Microcephaly, Sun Sensitivity, and Recurring