Certain drugs cause extreme intolerance in a 25-year-old man. His responses to various medicines have required hospitalization on two occasions. The following chart depicts his family lineage in relation to this ailment, with the red arrow denoting his place within the family. Assuming that the genetic condition demonstrates complete penetrance and is rare in the general population, which of the following inheritance patterns is most likely?

Question

Certain drugs cause extreme intolerance in a 25-year-old man. His responses to various medicines have required hospitalization on two occasions. The following chart depicts his family lineage in relation to this ailment, with the red arrow denoting his place within the family.  Assuming that the genetic condition demonstrates complete penetrance and is rare in the general population, which of the following inheritance patterns is most likely?

Quizplus · Accepted Answer

Eductional Objective: In X-linked recessive inheritance, 1) afflicted men will always create unaffected sons and carrier daughters, and 2) carrier females will produce affected sons and carrier daughters 50% of the time. G6PD deficiency is inherited in this manner and produces severe hemolytic anemia in response to oxidant medications.

Certain Drugs Cause Extreme Intolerance in a 25-Year-Old Man