A 37-year-old man comes to the emergency department because of increasing pain and tenderness in his right forearm. During a bar brawl 6 days earlier, he sustained a 4-cm laceration through the skin and subcutaneous tissue of his forearm. Treatment at the time of injury included cleaning and dressing the wound. Physical examination shows erythema surrounding the wound site and expression of yellow pus when pressure is applied adjacent to the wound. Which of the following molecules is most likely responsible for causing accumulation of pus over this patient's wound?

Question

A 37-year-old man comes to the emergency department because of increasing pain and tenderness in his right forearm.  During a bar brawl 6 days earlier, he sustained a 4-cm laceration through the skin and subcutaneous tissue of his forearm.  Treatment at the time of injury included cleaning and dressing the wound.  Physical examination shows erythema surrounding the wound site and expression of yellow pus when pressure is applied adjacent to the wound.  Which of the following molecules is most likely responsible for causing accumulation of pus over this patient's wound?

Quizplus · Accepted Answer

Eductional Objective: Interleukin-8 is a chemokine produced by macrophages that induces chemotaxis and phagocytosis in neutrophils. Other significant chemotactic agents include leukotriene B₄, 5-HETE (the leukotriene precursor), and complement component C5a.

A 37-Year-Old Man Comes to the Emergency Department Because of Increasing