A 10-year-old boy is brought to the emergency department because of a history of increasing tiredness and exertional dyspnea over the past two days. Three days ago, he was diagnosed with a urinary tract infection and was treated with nitrofurantoin. There is no personal history of serious illness. His parents emigrated from Kenya before he was born. Examination shows non-tender abdomen, and scleral icterus. Hemoglobin is 7.4 g/dL and mean corpuscular volume is 90 µm³. Which of the following additional findings are most likely present in this patient?

Question

Quizplus · Accepted Answer

Eductional Objective: Glucose-6-phosphate dehydrogenase deficiency presents with signs of anemia (eg, fatigue, pallor) and hemolysis (eg, jaundice, dark urine) after oxidative stress (eg, sulfa drug).  Hemolysis is associated with reticulocytosis, increased lactate dehydrogenase, decreased haptoglobin, and elevated indirect bilirubin.

A 10-Year-Old Boy Is Brought to the Emergency Department Because