As a Hypothetical Approach to Treating the Hyperglycemia Associated with Type

As a hypothetical approach to treating the hyperglycemia associated with Type 2 diabetes, a drug firm proposes to develop an inhibitor of liver glycogen phosphorylase. What is the biochemical rationale for this approach to inducing hypoglycemia?

A) hepatic fatty acid oxidation will decrease leading to reduced energy production needed for gluconeogenesis
B) hepatocytes will have a reduced capacity to store glucose following meals
C) liver glucose output will be reduced early during fasting
D) the resultant increase in glycogen storage will inhibit glucose uptake by the liver leading to increased utilization in skeletal muscle
E) there will be an increase in hepatic gluconeogenesis