Researchers are developing a new glycopeptide antibiotic similar to vancomycin. Susceptibility testing reveals that the new drug is bactericidal against gram-positive organisms at serum concentrations above 15 mcg/mL. Two different dosage regimens are developed to achieve a target serum trough concentration of 15-20 mcg/mL: one administered as 1 gram every 6 hours and the other as 2 grams every 12 hours. The two regimens are tested in healthy volunteers during an early-phase clinical trial, and the following pharmacokinetic profiles are obtained.
Compared to the 12-hour dosing regimen, the 6-hour regimen is most likely to exhibit which of the following features?

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The Answer of Researchers are developing a new glycopeptide antibiotic similar to vancomycin. Susceptibility testing reveals that the new drug is bactericidal against gram-positive organisms at serum concentrations above 15 mcg/mL. Two different dosage regimens are developed to achieve a target serum trough concentration of 15-20 mcg/mL: one administered as 1 gram every 6 hours and the other as 2 grams every 12 hours. The two regimens are tested in healthy volunteers during an early-phase clinical trial, and the following pharmacokinetic profiles are obtained.
Compared to the 12-hour dosing regimen, the 6-hour regimen is most likely to exhibit which of the following features?

Researchers Are Developing a New Glycopeptide Antibiotic Similar to Vancomycin