Which processes of drug response are most subject to genetic variation?
A)Drug dissolution in body fluids and drug binding to plasma proteins
B)Rates of drug movement into and through the gastrointestinal tract
C)Drug activation or deactivation and duration of drug actions
D)Drug binding with receptors and drug blocking of receptors

Question

Quizplus · Accepted Answer

Drug activation and deactivation are part of the pharmacodynamics, which involves drug metabolism and elimination. The enzymes involved in these processes influence the duration of drug actions. These responses are controlled by specific genes and thus are most subject to genetic variation. Drug dissolution is related to the chemical structure of the drug. Binding with plasma proteins is related to the amount of plasma proteins and the structure of the drug rather than genetic influences. The rate of drug movement within the gastrointestinal tract is variable, but the variation is physical rather than genetic. Although the number of receptors is genetically controlled, the ability of a drug to bind with a receptor functionally or nonfunctionally (blocking it) is mostly related to the structure of the drug.

Which Processes of Drug Response Are Most Subject to Genetic