Hypercholesterolemic Patients Taking 3-Hydroxy-3-Methylglutaryl-Coenzyme a (HMG-CoA) Reductase Inhibitors (Statins) Produce
Hypercholesterolemic patients taking 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) produce less cholesterol from endogenous synthesis.Lower intracellular cholesterol levels induce which of the following regulatory changes?
A) Enhanced VLDL formation in the liver.
B) Down-regulation of HMG-CoA reductase.
C) Higher lipoprotein lipase (LPL) activity.
D) Higher plasma chylomicron concentration.
E) An increased number of LDL receptors.
Correct Answer:
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