Statins Are the Most Important Type of Cholesterol-Lowering Drug, and They

Statins are the most important type of cholesterol-lowering drug, and they lower specifically LDL rather than HDL cholesterol.How do the statins lower LDL cholesterol?

A) By reducing the synthesis of apolipoprotein B-100, the major structural protein of VLDL and LDL.
B) By stimulating the conversion of excess cholesterol to bile acids in the liver, thereby depleting cholesterol for LDL synthesis.
C) By stimulating the transfer of cholesterol esters from VLDL and LDL to HDL.
D) By inhibiting HMG-CoA reductase, thereby preventing cholesterol synthesis and forcing the cells to obtain their cholesterol from LDL.
E) By stimulating the efflux of free cholesterol from cell membranes to HDL, thereby reducing the amount of cholesterol that is partitioned into LDL.