The net decrease in negative charge in the hemoglobin S molecule is responsible for what laboratory finding?

Question

Quizplus · Accepted Answer

The net decrease in negative charge in the hemoglobin S molecule results in a change in its electrophoretic mobility, which can be detected by laboratory tests such as hemoglobin electrophoresis. This is a key diagnostic test for sickle cell anemia. Solubility, oxygen affinity, and red blood cell flexibility are also affected by the hemoglobin S mutation, but they are not directly related to the net decrease in negative charge.

The Net Decrease in Negative Charge in the Hemoglobin S