In Hemoglobin C disease how does the mutation affect the hemoglobin molecule?

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In Hemoglobin C disease, there is a mutation in the beta-globin gene that results in the replacement of the amino acid glutamic acid with lysine at the sixth position of the beta chain. This causes the hemoglobin molecule to form insoluble aggregates, or crystals, under certain conditions, such as low oxygen tension, dehydration, or acidosis. These aggregates can cause blockages in blood vessels, leading to organ damage or a painful condition called sickle cell crisis. However, unlike in sickle cell disease, the deformability of red blood cells in Hemoglobin C disease is usually not affected, and the symptoms tend to be milder.

In Hemoglobin C Disease How Does the Mutation Affect the Hemoglobin