Which principle is used in DNA microarrays to differentiate between a wild-type allele and a disease allele that differs at only one nucleotide?
A)Copy number variation
B)Differences in DNA hybridization
C)Polymerase chain reaction
D)Locus heterogeneity

Question

Quizplus · Accepted Answer

DNA microarrays use differences in DNA hybridization to differentiate between a wild-type allele and a disease allele that differs at only one nucleotide. Small differences in the DNA sequence affect the hybridization between the probe and target DNA, allowing for detection of single nucleotide polymorphisms (SNPs) that can determine if an individual has a disease allele or not.

Which Principle Is Used in DNA Microarrays to Differentiate Between