Which one of the following statements regarding creatinine is correct?

Question

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Serum creatinine levels are primarily influenced by muscle mass, hence the intraindividual variation in serum creatinine is mainly due to muscle mass. B is incorrect as renal disease can increase or decrease serum creatinine levels depending on the severity of the disease. C is incorrect as elevated serum creatinine levels indicate decreased renal function and therefore decreased creatinine production. D is incorrect as creatinine is filtered and excreted by the renal tubules.

Which One of the Following Statements Regarding Creatinine Is Correct