Protoporphyrin synthesis begins in the mitochondria with the formation of __________ from glycine and succinyl CoA, which is the major rate-limiting step in heme synthesis.

Question

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The synthesis of protoporphyrin begins with the formation of delta aminolevulinic acid (D-ALA) in the mitochondria. D-ALA is synthesized from glycine and succinyl CoA, and this step is considered the major rate-limiting step in heme synthesis. Porphobilinogen (PBG), uroporphyrinogen (UPG), and coproporphyrinogen (CPG) are intermediate molecules in the heme synthesis pathway, but they are not the starting molecule.

Protoporphyrin Synthesis Begins in the Mitochondria with the Formation of __________