Which of the following RBC metabolic pathways produces the pyridine nucleotide NADPH from NADP⁺ along with reduced glutathione to provide the main line of defense against oxidative injury?

Question

Quizplus · Accepted Answer

The hexose monophosphate pathway (also known as pentose phosphate pathway or phosphogluconate pathway) produces NADPH from NADP+ and is the main pathway for generating reduced glutathione in RBCs. This provides protection against oxidative stress and injury. The other pathways listed (Embden-Meyerhof, Methemoglobin reductase, Luebering-Rapaport) do not produce NADPH from NADP+ and do not provide the same type of protection against oxidative stress in RBCs.

Which of the Following RBC Metabolic Pathways Produces the Pyridine