The ob/ob mouse is obese because it eats uncontrollably. By studying ob/ob mice, scientists discovered _____, a satiety signal that ob/ob mice cannot make because of a genetic mutation.

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By studying ob/ob mice, scientists discovered leptin, a satiety signal that these mice cannot make due to a genetic mutation. Ghrelin is a hormone that stimulates appetite, the soluble leptin receptor is a protein that binds to leptin and affects its activity, and the db gene product is a protein involved in regulating leptin signaling. None of these are the satiety signal missing in ob/ob mice.

The Ob/ob Mouse Is Obese Because It Eats Uncontrollably