In a eukaryote, one would expect to find the lowest rate of nonsynonymous nucleotide substitutions in an

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Nonsynonymous substitutions result in changes to the amino acid sequence of a protein, which can affect its function. Exons of protein-coding genes are under strong selective pressure to maintain the correct amino acid sequence, as mutations that affect protein function can be deleterious. In contrast, introns and pseudogenes are not under the same selective pressure, so nonsynonymous substitutions are expected to occur more frequently in these regions. Therefore, the lowest rate of nonsynonymous substitutions is expected in the exons of protein-coding genes.

In a Eukaryote, One Would Expect to Find the Lowest