Which Statement About Mutations Is False

Which statement about mutations is false?

A) A silent mutation results in no change in the amino acid sequence of a protein.
B) According to the neutral theory of molecular evolution, most substitution mutations are selectively neutral and accumulate through genetic drift.
C) A base substitution mutation in the third codon position is more likely to be neutral than a substitution at the first or second codon position.
D) Nonsynonymous mutations are virtually always deleterious to the organism.
E) The rate of fixation of neutral mutations is equal to the mutation rate and is independent of population size.