Which Observation Is Contrary to the Neutral Theory of Molecular

Which observation is contrary to the neutral theory of molecular evolution?

A) Rates of substitution are higher in pseudogenes.
B) The rates of evolution of a gene in different lineages of birds do not correlate with the population sizes of those birds.
C) In bats, the rate of synonymous substitutions at the GY1 gene is much higher than the rate of nonsynonymous substitutions.
D) The majority of variants confer neither an advantage nor a disadvantage on their bearers.
E) Variants within populations that arise because of genetic drift are always advantageous.