NRF2 is a transcription factor that is required to induce anti-oxidant genes, such as glutathione-S-transferase genes, in response to reactive oxygen and reactive nitrogen species released by inflammatory cells in the airways following phagocytosis of inhaled particles. Mice deficient in Nrf2 were tested for their allergic airway response to inhaled allergens in comparison to wild-type controls. Compared to wild type mice, the Nrf2^-/- mice would be expected to show:

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Quizplus · Accepted Answer

Nrf2 is involved in the induction of antioxidant genes that protect against oxidative stress. Mice deficient in Nrf2 would have impaired antioxidant defenses, leading to increased damage and inflammation in response to allergens. This would likely result in an enhanced Th2 immune response, characterized by increased levels of IL-4 and IL-13, which are key cytokines in the allergic response.

NRF2 Is a Transcription Factor That Is Required to Induce