Individuals with Peanut Allergies Can Exhibit a Variety of Symptoms

Individuals with peanut allergies can exhibit a variety of symptoms following exposure to the peanut allergen. These symptoms can include a runny nose, skin reactions such as hives, itching in the mouth and throat, digestive problems such as cramps, diarrhea or vomiting, and shortness of breath or wheezing. This variety of symptoms is a result of:

A) Systemic production of inflammatory mediators causing responses in many tissues
B) The presence of mast cells with pre-bound IgE in all mucosal tissues
C) The simultaneous exposure of skin, oral mucosa, throat, and gastrointestinal tract to an ingested allergen
D) The high concentrations of histamine present in pre-stored mast cell granules
E) The presence of high concentrations of monomeric IgE in the circulation