Genome-wide association studies of large cohorts of individuals (5000 allergic versus 10,000 controls) with IgE-mediated allergies revealed a set of genes significantly correlated with atopy. Further studies of the top ten candidate genes indicated that each gene showed allelic variations that were likely associated with differences in gene expression. One of these ten genes encodes STAT6, the transcription factor activated downstream of the IL-4 receptor. What would you predict for the allelic variant of STAT6 found more frequently in allergic individuals compared to the allele found more frequently in non-allergic controls?

Question

Genome-wide association studies of large cohorts of individuals (>5000 allergic versus >10,000 controls) with IgE-mediated allergies revealed a set of genes significantly correlated with atopy. Further studies of the top ten candidate genes indicated that each gene showed allelic variations that were likely associated with differences in gene expression. One of these ten genes encodes STAT6, the transcription factor activated downstream of the IL-4 receptor. What would you predict for the allelic variant of STAT6 found more frequently in allergic individuals compared to the allele found more frequently in non-allergic controls?

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The Answer of Genome-wide association studies of large cohorts of individuals (>5000 allergic versus >10,000 controls) with IgE-mediated allergies revealed a set of genes significantly correlated with atopy. Further studies of the top ten candidate genes indicated that each gene showed allelic variations that were likely associated with differences in gene expression. One of these ten genes encodes STAT6, the transcription factor activated downstream of the IL-4 receptor. What would you predict for the allelic variant of STAT6 found more frequently in allergic individuals compared to the allele found more frequently in non-allergic controls?

Genome-Wide Association Studies of Large Cohorts of Individuals (>5000 Allergic