Red Blood Cells Are Common Targets of Drug-Induced Anemia, a Disorder

Red blood cells are common targets of drug-induced anemia, a disorder that occurs when some drugs bind to the surface of red blood cells and trigger the development of IgG antibodies that bind to the drug-coated red blood cell and promote red blood cell destruction. Since the drug binding to the red blood cell surface does not actually harm the red blood cell, the anemia resulting in this disorder is caused by:

A) Activation of the complement cascade leading to red blood cell lysis
B) Trapping of red blood cells on large endothelial vessels
C) Phagocytosis by Fc $\gamma$ -receptor expressing macrophages in the spleen
D) Stimulation of CD4 T cells recognizing modified red blood cell surface proteins formed by the binding of the drug
E) Stimulation of CD8 cytotoxic T cells that recognize drug-self protein conjugates and are triggered to kill the red blood cells