Reovirus is an enteric virus that infects mice by adhering to intestinal M cells and then using M cell transport to enter Peyer's patches. Mice that were orally inoculated with reovirus cleared the primary infection, and upon secondary challenge 21 days later, had no detectable virus in their Peyer's patches. In contrast, naive controls that did not receive the primary inoculation had 10³PFU of virus/mg of tissue following oral challenge with virus. The protective response induced by the primary oral inoculation would also be eliminated in: A) FcRn-deficient mice B) IgA-deficient mice C) IgM-deficient mice D) Fc$\gamma$RI-deficient mice E) IgG-deficient mice

Question

Reovirus is an enteric virus that infects mice by adhering to intestinal M cells and then using M cell transport to enter Peyer's patches. Mice that were orally inoculated with reovirus cleared the primary infection, and upon secondary challenge 21 days later, had no detectable virus in their Peyer's patches. In contrast, naive controls that did not receive the primary inoculation had >10³PFU of virus/mg of tissue following oral challenge with virus. The protective response induced by the primary oral inoculation would also be eliminated in: A) FcRn-deficient mice B) IgA-deficient mice C) IgM-deficient mice D) Fc$\gamma$RI-deficient mice E) IgG-deficient mice

Quizplus · Accepted Answer

The protective response induced by the primary oral inoculation is likely mediated by the production of IgA antibodies, which are transported across the intestinal epithelium by the polymeric Ig receptor (pIgR) on the basolateral surface of epithelial cells. IgA-deficient mice would not be able to produce these antibodies, and thus the protective response induced by the primary inoculation would be eliminated. FcRn-deficient mice and IgG-deficient mice would not be directly affected by the absence of IgA, and IgM and FcR-gamma RI are not typically involved in mucosal immunity.

Reovirus Is an Enteric Virus That Infects Mice by Adhering γ\gammaγ

Reovirus Is an Enteric Virus That Infects Mice by Adhering $\gamma$