Infections of intracellular pathogens (e.g., mycobacteria, listeria, toxoplasma, viruses, etc.) cause a rise in the numbers of monocytes in the blood, a symptom known as monocytosis. In the cases of these infections, monocytosis is likely caused by: A) Increased production of monocytes in the bone marrow induced by T_H1 cytokines B) Loss of monocytes into tissues due to inflammation, leading to increased production in the bone marrow C) Differentiation of blood monocytes into macrophages, inducing bone marrow production of new monocytes D) Sticking of blood monocytes to vessel walls due to integrin binding, reducing the numbers of monocytes in the circulation E) Apoptosis of monocytes caused by the toxic effects of the infecting pathogen

Question

Quizplus · Accepted Answer

In response to infections caused by intracellular pathogens, T_H1 cytokines induce the production of monocytes in the bone marrow, leading to a rise in their numbers in the blood. This process is known as monocytosis. The other options are not supported by current scientific understanding of monocytosis.

Infections of Intracellular Pathogens (E